COMPARATIVE ANALYSIS OF PHYSIOLOGICAL AND HISTOLOGICAL EFFECTS OF E-CIGARETTE VS. CONVENTIONAL SMOKING IN ALBINO MICE

Abstract

This study compares the physiological and histological effects of e-cigarette (T1) and conventional cigarette (T2) exposure in albino mice over nine weeks. Both groups showed decreased hemoglobin levels, with T1 exhibiting higher white blood cell and platelet counts. Testosterone was elevated in T2, while glucose and estrogen levels increased in T1 but decreased in T2. Histological analysis revealed myocardial damage, glomerulosclerosis, liver cell ballooning, and lung emphysema in both groups, more severe in T2. Both exposures caused weight loss, especially in males. Findings suggest that while both vaping and smoking adversely affect health, e-cigarettes may cause greater immune and hormonal disruption alongside significant blood and tissue damage.